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XIAP, a member of the inhibitor of apoptosis family of proteins, is a critical regulator of apoptosis. Inhibition of the BIR domain-caspase interaction is a ...
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Formation of a survivin-XIAP complex promotes increased XIAP stability against ubiquitination/proteasomal destruction and synergistic inhibition of apoptosis, ...
This implies that the functions of IAP proteins are much more complex than simple protection against cell death by binding caspases. In the case of XIAP, the ...
Jun 24, 2004 · Formation of a survivin-XIAP complex promotes increased XIAP stability against ubiquitination/proteasomal destruction and synergistic inhibition ...
X-linked inhibitor of apoptosis (XIAP) is an inhibitor of apoptosis ... XIAP associates with the active caspase-9-Apaf-1 holoenzyme complex ... cancer cells.177 ...
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Aug 16, 2002 · We recently demonstrated that X-linked inhibitor-of-apoptosis protein (XIAP) associates with the apoptosome in vitro. By utilizing XIAP mutants, ...
Abstract. The inhibitor of apoptosis proteins (IAPs) are a family of antiapoptotic proteins that bind and inhibit caspases 3, 7, and/or 9, but not caspase.
Nov 10, 2009 · Malignant cells resist apoptosis through over-expression of inhibitor of apoptosis proteins (IAPs), such as X-linked IAP (XIAP). Methods: A ...
XIAP is a direct inhibitor of caspase-3 and -7, and suppresses the mitochondrial apoptotic pathway by inhibiting caspase-9 [32].
Oct 7, 2013 · Optimization of Benzodiazepinones as Selective Inhibitors of the X-Linked Inhibitor of Apoptosis Protein (XIAP) Second Baculovirus IAP Repeat ( ...